Plate with hole

Case 1:

Von Mises: 6.0436e5 Pa

Max. Principle Stress: 6.193e5 Pa

Total Deformation: .000275 mm

Yield stress: 250e6 Pa

FOS: 413.66

Case 2:

Von Mises: 5.813e5 Pa

Max. Principle Stress: 5.97e5 Pa

Total Deformation: .000297 mm

Yield stress: 250e6 Pa

FOS: 430.07

By Comparing Both the cases: Case 2 is more safer, because of FOS value is more

By manufacturing standpoint: By considering manufacturing standpoint both are manufacturable. I select Case 2, because its more safer.